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At the start of a clinical trial, each participant has one of two potential outcomes:
one outcome if they are assigned to the treatment group or
one if they are assigned to the control group.
Their digital twin forecasts their potential control group outcome regardless of their actual assignment in the clinical trial.
Participants’ digital twins are used in TwinRCTs, highly powered trials with smaller control groups.
TwinRCTs improve the ability to observe treatment effects in early stage studies by increasing power without adding more patients.
TwinRCTs reach full enrollment sooner because they require fewer patients to achieve the same power as traditional trial designs.